Ringing in the Changes!

Ringing the changes

JCS in 2010 - ringing in the changes.

Calcium signalling: Ringing changes to the ‘bell-shaped curve’

The stimulation of cells with agonists that activate phospholipase C, and hence increase the cytoplasmic concentration of inositol 1,4,5-trisphosphate (IP3), often produces complex intracellular Ca2+ signals, such as Ca2+ waves [1]. The key to understanding how Ca2+ waves propagate was the observation that the Ca2+ wave velocity and concentration gradient was maintained as the Ca2+ waves swept ...

Ringing in the New Year

www.landesbioscience.com oxidative Medicine and cellular Longevity 1 The excitement and enthusiasm for the New Year brings with it new thoughts and innovative promises for pioneering avenues of drug discovery and new treatment strategies for a host of disorders. Such thinking is not only optimistic, but also necessary considering the economic costs healthcare brings to any country. For example,...

The emergence of ringing vertigo.

Ding dongmerrily on high, goes the famous Christmas carol, but for some of the United Kingdom’s 40 000 campanologists the bells have not been ringing so merrily. Instead, church bell ringers have this year been complaining of a disorder that has been forcing them to abandon their towers and steeples and seek out hypnotherapists and counsellors in search of a cure. Symptoms include vertigo, a se...